A survey of RNA secondary structural propensity encoded within human herpesvirus genomes: global comparisons and local motifs.
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There are 9 herpesviruses known to infect humans, of which Epstein–Barr virus (EBV) is the most widely distributed (>90% of adults infected). This ubiquitous virus is implicated in a variety of cancers and autoimmune diseases. Previous analyses of the EBV genome revealed numerous regions with evidence of generating unusually stable and conserved RNA secondary structures and led to the discovery of a novel class of EBV non-coding (nc)RNAs: the stable intronic sequence (sis)RNAs. Read more about A survey of RNA secondary structural propensity encoded within human herpesvirus genomes: global comparisons and local motifs.